November 2014

Monthly Archive

Chinese medicine syndrome distribution of chronic hepatitis B virus carriers in immunotolerant phase.

Posted by on 13 Nov 2014 | Tagged as: Hepatitis B Alternative Medicine

Related Articles Chinese medicine syndrome distribution of chronic hepatitis B virus carriers in immunotolerant phase. Chin J Integr Med. 2014 Feb;20(2):94-100 Authors: Xie HP, Yang HZ, Wu WK, Guan WB, Ke QS, Li YW, Dai M, Xiao GM, Zhang JS, Li YM Abstract OBJECTIVE: To explore Chinese medicine (CM) syndrome distribution of chronic hepatitis B virus (HBV) carriers in immunotolerant phase (ITP). METHODS: One hundred and eighty-five chronic HBV carriers in ITP, seen in the Third Affiliated Hospital of Sun Yat-sen University from May 2009 to December 2010, were admitted in an observational study under the guidance of CM. Patients’ CM symptoms and signs, demographics, liver biochemistries, and qualitative HBV DNA were recorded in the questionnaires. CM syndromes were then differentiated to 15 detailed types and analyzed by generalization. Lastly, the location, pathogenic factors and nature of the disease were also assessed. RESULTS: When CM syndrome patterns were differentiated to 15 types, there were 27 (15%) no syndrome cases, 94 (50%) single syndrome cases and 64 (35%) compound syndromes cases. The main detailed syndromes included Liver (Gan)-qi depression (LQD), Kidney (Shen)-qi deficiency (KQD), Spleen (Pi)-qi deficiency (SQD) and Kidney-yang deficiency (KYAD). After CM syndromes generalized to five types, their frequency was Spleen-Kidney deficiency (SKD)>LQD>inner dampness-heat retention (IDHR)>Liver-Kidney deficiency (LKD)>blood stasis blocking collateral (BSBC). SKD and LQD occupied 64%. The disease location included Liver, Gallbladder (Dan), Spleen, Stomach (Wei) and Kidney. The pathogenic factors were mainly qi stagnation, qi deficiency, yang deficiency, concurrently dampness-heat and blood stasis. The deficiency syndrome was more than excess syndrome in its nature. CONCLUSIONS: Most of chronic HBV carriers in ITP have their CM syndrome, and the most common types are SKAD, LQD. This study suggests that the natural history may be improved through breaking the state of immune tolerance or shorten the time of ITP by strengthening Spleen-Kidney and reliving Liver qi. PMID: 24619234 [PubMed – indexed for MEDLINE]

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Chinese medicine syndrome distribution of chronic hepatitis B virus carriers in immunotolerant phase.

Four homoisoflavonoids isolated from traditional Chinese medicine: "gan luo xin".

Posted by on 02 Nov 2014 | Tagged as: Hepatitis B Alternative Medicine

Related Articles Four homoisoflavonoids isolated from traditional Chinese medicine: “gan luo xin”. J Asian Nat Prod Res. 2014;16(8):813-8 Authors: Li LM, Yuan QP, Chen G Abstract Two new homoisoflavonoids, ( ± )-5,7-dihydroxy-8-methyl-3-(2′,4′-dihydroxybenzyl) chroman-4-one (1) and ( ± )-5,7-dihydroxy-6,8-dimethyl-3-(2′,4′-dihydroxybenzyl) chroman-4-one (2), along with two known homoisoflavonoids, 5,7-dihydroxy-6-methyl-3-(2′,4′-dihydroxybenzyl)chroman-4-one (3) and disporopsin (4), were isolated from the EtOAc extract of traditional Chinese medicine–“Gan Luo Xin.” Their structures were determined on the basis of spectroscopic analysis (UV, IR, HR-ESI-MS, 1D NMR, and 2D NMR). PMID: 24993400 [PubMed – indexed for MEDLINE]

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Four homoisoflavonoids isolated from traditional Chinese medicine: "gan luo xin".

Liver Stiffness Measurement-Based Scoring System for Significant Inflammation Related to Chronic Hepatitis B.

Posted by on 02 Nov 2014 | Tagged as: Hepatitis B Alternative Medicine

Related Articles Liver Stiffness Measurement-Based Scoring System for Significant Inflammation Related to Chronic Hepatitis B. PLoS One. 2014;9(10):e111641 Authors: Hong MZ, Zhang RM, Chen GL, Huang WQ, Min F, Chen T, Xu JC, Pan JS Abstract OBJECTIVES: Liver biopsy is indispensable because liver stiffness measurement alone cannot provide information on intrahepatic inflammation. However, the presence of fibrosis highly correlates with inflammation. We constructed a noninvasive model to determine significant inflammation in chronic hepatitis B patients by using liver stiffness measurement and serum markers. METHODS: The training set included chronic hepatitis B patients (n = 327), and the validation set included 106 patients; liver biopsies were performed, liver histology was scored, and serum markers were investigated. All patients underwent liver stiffness measurement. RESULTS: An inflammation activity scoring system for significant inflammation was constructed. In the training set, the area under the curve, sensitivity, and specificity of the fibrosis-based activity score were 0.964, 91.9%, and 90.8% in the HBeAg(+) patients and 0.978, 85.0%, and 94.0% in the HBeAg(-) patients, respectively. In the validation set, the area under the curve, sensitivity, and specificity of the fibrosis-based activity score were 0.971, 90.5%, and 92.5% in the HBeAg(+) patients and 0.977, 95.2%, and 95.8% in the HBeAg(-) patients. The liver stiffness measurement-based activity score was comparable to that of the fibrosis-based activity score in both HBeAg(+) and HBeAg(-) patients for recognizing significant inflammation (G ≥3). CONCLUSIONS: Significant inflammation can be accurately predicted by this novel method. The liver stiffness measurement-based scoring system can be used without the aid of computers and provides a noninvasive alternative for the prediction of chronic hepatitis B-related significant inflammation. PMID: 25360742 [PubMed – as supplied by publisher]

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Liver Stiffness Measurement-Based Scoring System for Significant Inflammation Related to Chronic Hepatitis B.