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Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and…

Posted by on 12 Aug 2014 | Tagged as: Hepatitis B Alternative Medicine, Others

Related Articles Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features. Mod Pathol. 2013 Dec;26(12):1586-93 Authors: Wood LD, Heaphy CM, Daniel HD, Naini BV, Lassman CR, Arroyo MR, Kamel IR, Cosgrove DP, Boitnott JK, Meeker AK, Torbenson MS Abstract Hepatocellular carcinomas exhibit heterogeneous morphologies by routine light microscopy. Although some morphologies represent insignificant variations in growth patterns, others may represent unrecognized subtypes of hepatocellular carcinoma. Identification of these subtypes could lead to separation of hepatocellular carcinomas into discrete groups with unique underlying genetic changes, prognosis, or therapeutic responses. In order to identify potential subtypes, two pathologists independently screened a cohort of 219 unselected hepatocellular carcinoma resection specimens and divided cases into potential subtypes. One of these promising candidate subtypes was further evaluated using histological and molecular techniques. This subtype was characterized by a unique and consistent set of histological features: smooth chromophobic cytoplasm, abrupt focal nuclear anaplasia (small clusters of tumor cells with marked nuclear anaplasia in a background of tumor cells with bland nuclear cytology), and scattered microscopic pseudocysts–we designate this variant as ‘chromophobe hepatocellular carcinoma with abrupt anaplasia’. Thirteen cases were identified (6% of all hepatocellular carcinomas), including 6 men and 7 women with an average age of 61 years. Six cases occurred in cirrhotic livers. Serum AFP was elevated in 6 out of 10 cases. There were a variety of underlying liver diseases, but cases were enrichment for chronic hepatitis B, P=0.006. Interestingly, at the molecular level, this variant was strongly associated with the alternative lengthening of telomere (ALT) phenotype by telomere FISH. ALT is a telomerase-independent mechanism of telomere maintenance and is found in approximately 8% of unselected hepatocellular carcinomas. In contrast, 11/12 (92%) of the cases of chromophobe hepatocellular carcinoma with abrupt anaplasia were ALT-positive. In summary, we propose that chromophobe hepatocellular carcinoma with abrupt anaplasia represents a new subtype of hepatocellular carcinoma with unique morphological and molecular features. PMID: 23640129 [PubMed – indexed for MEDLINE]

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Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and…

Editing HPV's genes to kill cervical cancer cells – Medical Xpress

Posted by on 09 Aug 2014 | Tagged as: Cervical Cancer, Others

Using CRISPR to silence the E6 gene in Human Papilloma Virus, Duke researchers were able to re-start the cervical carcinoma cell's natural self-destruct mechanisms, including the gene p53. Similar results … "Because this approach is only going after viral genes, there should be no off-target effects on normal cells," said Bryan R. Cullen, Ph.D., senior study author and professor of molecular genetics and microbiology at Duke University School of Medicine . "You can …

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Editing HPV's genes to kill cervical cancer cells – Medical Xpress

Editing HPV's genes to kill cervical cancer cells | Science Codex

Posted by on 08 Aug 2014 | Tagged as: Cervical Cancer, Others

Using CRISPR to silence the E6 gene in Human Papilloma Virus, Duke researchers were able to re-start the cervical carcinoma cell's natural self-destruct mechanisms, including the gene p53. Similar results were obtained against the HPV-E7 gene, turning on … "This method has the potential to be a single hit treatment that will dramatically reduce tumor load without having any effect on normal cells." The researchers are also targeting other viruses that use DNA as …

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Editing HPV's genes to kill cervical cancer cells | Science Codex

Millions Given Access to Breast, Cervical Cancer Screening: CDC …

Posted by on 07 Aug 2014 | Tagged as: Cervical Cancer, Others

THURSDAY Aug. 7, 2014, 2014 — Millions of American women have benefited from a breast and cervical cancer screening program offered by the U.S. Centers for Disease Control and Prevention, according to a new report. The program was …

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Millions Given Access to Breast, Cervical Cancer Screening: CDC …

Ebola media overload, Jon Rappoport, PCR, sun exposure, ear …

Posted by on 05 Aug 2014 | Tagged as: Cervical Cancer, Others

Ebola media overload, Jon Rappoport, PCR, sun exposure, ear infection, cervical cancer , economic, political healing, therapy chickens & more! by Robert Scott Bell. The Robert Scott Bell Show August 5, 2014. New LIVE time slot! Tuesday on …

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Ebola media overload, Jon Rappoport, PCR, sun exposure, ear …

Patience Jonathan calls for urgent universal access to cervical …

Posted by on 24 Jul 2014 | Tagged as: Cervical Cancer, Others

Windhoek (Namibia) – The First Lady, Mrs Patience Jonathan, said there was the need to urgently address universal access to cervical cancer prevention and treatment in Africa. Jonathan said this at the 8th … She said that subsequently, hospitals that offered radiation therapy would be increased to 11. Jonathan advocated for the inclusion …. Why can't we research into the herbs which kept our forefathers healthy and strong without we… Read More → · Sweet Crude …

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Patience Jonathan calls for urgent universal access to cervical …

The Toda of South India: Culture and Medicinal Plants – Wildlife Vet …

Posted by on 23 Jul 2014 | Tagged as: Others, Philippine Medicinal Plants

In 1955 Joanne Van de Riet was a bright inquisitive teenager who was fascinated with the world around her. Two of her major hobbies were painting and flower pressing. When an anthropologist visited the family home in the …

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The Toda of South India: Culture and Medicinal Plants – Wildlife Vet …

Hair Eating Therapy Worksheet | trichotillomania psychological causes

Posted by on 22 Jul 2014 | Tagged as: Gallstone Alternative Medicine, Others

Some say that these are roundworms tapeworms and even by taking gall bladder stones treatment alternative medicine right? Teeth whitening strips … In holistic medicine is become widely available but they need. With the …

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Hair Eating Therapy Worksheet | trichotillomania psychological causes

Coconut Oil: From Diet to Therapy « Anvil Publishing, Inc.

Posted by on 22 Jul 2014 | Tagged as: Others, Philippine Medicinal Plants

He is among the earliest advocates of herbal medicine research in the Philippines . He is a founding member of the National Integrated Research Program on Medicinal Plants (NIRPROMP) under the Department of Science and Technology, …

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Coconut Oil: From Diet to Therapy « Anvil Publishing, Inc.

Cervical cancer prevention in BME communities: raising awareness …

Posted by on 14 Jul 2014 | Tagged as: Cervical Cancer, Others

To highlight Ethnic Minority Cancer Awareness Month, Jo's Cervical Cancer Trust and the NHS Cancer Screening programme are holding a free training day in Birmingham. The event aims to raise awareness of cervical  …

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Cervical cancer prevention in BME communities: raising awareness …

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