Emergence of oncogenic-enhancing hepatitis B virus X gene mutants in patients receiving suboptimal entecavir treatment. Hepatology. 2018 Dec 15;: Authors: Lin CL, Chu YD, Yeh CT Abstract Entecavir is a widely used nucleoside analogue for antiviral therapy against chronic hepatitis B virus (HBV) infection. Despite its remarkable efficacy in suppressing HBV replication, a substantial proportion of cirrhotic patients still developed hepatocellular carcinoma (HCC) after entecavir treatment (1). Presumably, it is largely attributed to the existing precancerous hepatocytes, which sturdily progresses into cancer despite effective viral suppression. HBV X (HBx) protein is a well-known oncogenic protein. Here, we explored an alternative possibility that oncogenic-enhancing mutations developed in HBx in HCC patients having received entecavir treatment. This article is protected by copyright. All rights reserved. PMID: 30552766 [PubMed – as supplied by publisher]

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Emergence of oncogenic-enhancing hepatitis B virus X gene mutants in patients receiving suboptimal entecavir treatment.